"There should be a different therapy for every patient because every patient is different"- William Dempsey (Abbott laboratories)
Treatment of erectile dysfunction, no longer remains an agonizing procedure, earlier ED was treated with injection or through surgery, both of these methods were extremely painful and embarrassing, and worst of all, the success was uncertain.
The emergence of Viagra, Levitra, and Cialis in 1998(FDA approved prescription drugs for erectile dysfunction) revolutionized the entire concept of the treatment of erectile dysfunction. These drugs provided millions of ED patients around the world with the opportunity to renew and re-stabilize their sexual life.
Levitra, Cialis and Viagra are all PDE type 5 inhibitors, they helps the blood vessels in the penis to relax, resulting in flow of blood which causes erection. They are all taken orally, and their basic adverse effects are somewhat familiar.
The worth of erectile dysfunction market has grown drastically, it is estimated that by the end of 2006 its income will be $6 billion. 15% of the total male population, nearly 300 million men around the world suffer from impotence and the numbers are not going to decline.
This phenomenal market magnetizes several companies to cash in, its no surprise that numerous companies are rushing in with new and efficient methodology to treat erectile dysfunction.
The information about the additional medical qualities of Apomorphine led to the innovation of Uprima. This sublingual tablet was launched by the Abbott laboratories U.K.
Uprima is a small tablet which dissolves quickly when placed under the tongue, leading to erection within 20 minutes.
What's new about Uprima?
UPRIMA is a dopamine receptor agonist that works in the brain to improve diminished erectile function by enhancing the natural signal to the penis following sexual stimulation, similar to the way men normally have erections. UPRIMA works through the central nervous system, producing a series of events that enhances the ability to achieve and maintain penile erection. It is distinct from other oral therapies, which act by blocking the action of certain enzymes involved in the erectile response.
Uprima provides plentiful benefits but the most important of all is that its onset is very fast and its effect is similar to natural erection. Some of the common side effects of Uprima are nausea, dizziness and headache, which were in general mild and momentary in nature.
Uprima Doses- Uprima is available in 2 mg and 3 mg doses.
Conclusion: The quality and the efficiency of Uprima may force other companies indulged in manufacture of erectile deficiency drugs to follow the same path.
Adam Parore is an associated editor to the website http://www.affordable-prescriptions.md AP is committed to provide visitors with complete information on men's health, sexual health, online prescription drugs like Levitra by latest news, personal views, men's health articles on erectile dysfunction related topics. Your feedback & comments will be highly appreciated at adam.parore@gmail.com
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Erectile dysfunction (ED) affects the lives of many middle-aged men and their partners. The term erectile dysfunction covers a range of disorders, but usually refers to the inability to obtain an adequate erection for satisfactory sexual activity.
Although erectile dysfunction, formerly called impotence, is more common in men older than 65, it can occur at any age. An occasional episode of erectile dysfunction happens to most men and is normal. As men age, it's also normal to experience changes in erectile function. Erections may take longer to develop, may not be as rigid or may require more direct stimulation to be achieved. Men may also notice that orgasms are less intense, the volume of ejaculate is reduced and recovery time increases between erections. Erectile dysfunction may also be a sign of a physical or emotional problem that requires treatment.
Erectile dysfunction was once a taboo subject, but more men are seeking help. Doctors are gaining a better understanding of what causes erectile dysfunction and are finding new and better treatments.
This Website discusses all about erectile dysfunction, physiology of the normal erection and the pathophysiology, and treatment of ED.
What is Erectile Dysfunction?
Erectile dysfunction or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. There are various underlying causes, such as diabetes, many of which are medically reversible.
The causes may be physiological or psychological. Psychological impotence can often be helped by almost anything that the patient believes in; there is a very strong placebo effect.
Due to its embarrassing nature and the shame felt by sufferers, the subject was taboo for a long time, and is the subject of many urban legends. Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of perhaps the first pharmacologically effective remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by the news-worthiness of stories about it and heavy advertising.
The Latin term impotentia coeundi describes simple inability to insert the penis into the vagina. It is now mostly replaced by more precise terms.
Signs and symptoms:
Erectile dysfunction is characterized by the inability to maintain erection. Normal erections during sleep and in the early morning suggest a psychogenic cause, while loss of these erections may signify underlying disease, often cardiovascular in origin. Other things leading to erectile dysfunction are diabetes mellitus (causing neuropathy) or hypogonadism (decreased testosterone levels due to disease affecting the testicles or the pituitary gland).
Here are some causes of Erectile Dysfunction:
* Arousal: The first step is sexual arousal, which men obtain from the senses of sight, touch, hearing and smell, and from thoughts.
* Nervous system response: The brain communicates the sexual excitation to the body's nervous system, which activates increased blood flow to the penis.
* Blood vessel response:. A relaxing action occurs in the blood vessels that supply the penis, allowing more blood to flow into the shafts that produce the erection.
Physiology of normal erections:
Penile erections involve an integration of complex physiologic processes involving the CNS, peripheral nervous system, and hormonal and vascular systems. Any abnormality involving these systems, whether from medication or disease, has a significant impact on the ability to develop and sustain an erection, ejaculate, and experience orgasm. Tumescence, the vascular filling of the cavernous bodies, relies on neural and hormonal mechanisms operating at various levels of the neural axis. This is unique among visceral functions because it requires central neurological input.
Andersson et al summarized some of the information related to the pathways involved in erectile function. The degree of contraction of corpus cavernosal smooth muscle determines the functional state of the penis. The balance between contraction and relaxation is controlled by central and peripheral factors that involve many transmitters and transmitter systems. At the cellular level, smooth muscle relaxation occurs following the release of acetylcholine from the parasympathetic nerves.
Pathophysiology of erectile dysfunction:
Erectile Dysfunction is essentially a vascular disease. It is often associated with other vascular diseases and conditions such as diabetes, hypertension, and coronary artery disease. Other conditions associated with Erectile Dysfunction include neurologic disorders, endocrinopathies, benign prostatic hyperplasia, and depression. Conditions associated with reduced nerve and endothelium function, such as aging, hypertension, smoking, hypercholesterolemia, and diabetes, alter the balance between contraction and relaxation factors. These conditions cause circulatory and structural changes in penile tissues, resulting in arterial insufficiency and defective smooth muscle relaxation. In some patients, sexual dysfunction may be the presenting symptom of these disorders.
Treatment:
Sildenafil Citrate is the way to treat Erectile Dysfunction. Generic Viagra contains sildenafil citrate and contains same ingredients like branded drug.
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